Reversal of doxorubicin resistance by adenovirus- mediated transfer of cyclooxygenase-2 antisense in multidrug-resistant MCF-7 cells
نویسندگان
چکیده
Department of Obstetrics & Gynecology, University of Texas Medical Branch, Galveston, Texas, USA Department of Pharmacology and Experimental Oncology, Cancer Biology, National Cancer Institute, Cairo University, Egypt Department of Pharmacology, Faculty of Pharmacy, Cairo University, Cairo, Egypt __________________________________________________________________________________ *Correspondence: Ayman Al-Hendy, MD, PhD, FRCSC, FACOG, Department of Obstetrics & Gynecology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555, USA; Telephone: (409) 747-1668; Fax: (409) 747-1669; email: [email protected]
منابع مشابه
Inhibition of Akt phosphorylation attenuates resistance to TNF-α cytotoxic effects in MCF-7 cells, but not in their doxorubicin resistant derivatives
Objective(s): Acquisition of TNF-α resistance plays role in the onset and growth of malignant tumors. Previous studies have demonstrated that MCF-7 cell line and its doxorubicin resistant variant MCF-7/Adr are resistant against the cytotoxic effects of TNF-α. In this study, we investigated the role of Akt activation in resistance of MCF-7 and MCF-7/Adr against TNF-α cytotoxicity. Materials and ...
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